Amplitude of low-frequency fluctuations in bipolar disorder

Xu, K., Liu, H., Li, H., Tang, Y., Womer, F., Jiang, X., Chen, K., Zhou, Y., Jiang, W., Luo, X., Fan, G., & Wang, F. (2014). Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study. Journal of Affective Disorders, 152–154, 237–242
Authors
Ke Xu; Hu Liu; Huanhuan Li; Yanqing Tang; Fay Womer; Xiaowei Jiang; Kaiyuan Chen; Yifang Zhou; Wenyan Jiang; Xingguang Luo; Guoguang Fan; Fei Wang – Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang
Abstract
The spontaneous low frequency fluctuations (LFF) of blood oxygenation level-dependent (BOLD) signal in resting state have been identified as a biological measure of baseline spontaneous activity in the brain. Increasingly, studies of spontaneous resting state functional connectivity have demonstrated neural network abnormalities in bipolar disorder (BD). This study used the amplitude of low frequency fluctuations (ALFF) to explore the regional functional changes in BD during resting state. Compared to the HC group, the BD group showed increased ALFF in ventral prefrontal cortex, dorsallateral prefrontal cortex, frontal eye field, insula, and putamen with extension into the ventral striatum, as well as decreased ALFF in the lingual gyrus (p<0.05, corrected). Our results revealed altered regional brain activity in BD during resting state. The affected regions have been associated with BD pathophysiology.
Keywords
Bipolar disorder; Amplitude of low frequency fluctuation; Resting state; Spontaneous brain activity
Weblink
http://www.ncbi.nlm.nih.gov/pubmed/24120087